![]() ![]() ![]() This expanded monoclonal protein testing panel provides the highest diagnostic sensitivity for the monoclonal light chain diseases such as primary amyloidosis and light chain deposition disease disorders that often do not have serum monoclonal proteins in high enough concentration to be detected and quantitated by SPE. ![]() In addition, the MALDI-TOF method can detect glycosylated light chains that have been demonstrated to be a risk factor for amyloidosis. The detection of M-proteins by matrix-assisted laser desorption/ionization-time of flight mass spectrometry ( MALDI-TOF MS) has shown to be more analytically and clinically sensitive than immunofixation. If amyloidosis is suspected, a 24-hour monoclonal protein studies should be performed. The International Myeloma Working Group guidelines state that to adequately screen for a monoclonal protein, serum protein electrophoresis (SPE), immunofixation electrophoresis, and a serum free light chain (FLC) analysis should all be used. Monoclonal proteins are markers of plasma cell proliferative disorders. ![]()
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